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Breeding: The future for IVF treatment in cattle

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In-vitro fertilisation (IVF) treatment to speed up genetic advancement in cattle is a relatively new technique, but it is predicted to become a mainstream breeding tool over the next five to 10 years.

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Cattle in-vitro fertilisation (IVF) programmes were just getting underway in this country when the foot-and-mouth epidemic started, says vet David Black, of the Cumbria-based advanced breeding technology consortium, Activf-ET.

 

The disease halted progress and led to the UK falling behind other countries, such as the USA, South America and Canada.

 

However, Mr Black believes IVF will soon overtake multiple ovulation embryo transfer (MOET) as a breeding technique, due to the greater benefits it offers.

 

He says: “IVF is standard practice in humans, where it is often perceived as a last resort for couples whose fertility might be compromised.

 

“Unsurprisingly, the same process used on cattle is sometimes viewed in a similar light.

 

“Bovine IVF gives producers the chance to breed from a virgin heifer, a pregnant cow, or an animal with high genetic merit which cannot get in-calf.

 

“A cow can have a low grade uterine infection which is not linked to her breeding history in any way, for example.

 

“Her embryos can be harvested, fertilised and placed in a surrogate.

 

“The practice is not intended to be used only on animals which are inherently infertile; it is very effective in cows of normal fertility, and this is where the future lies.”

 

The differences between a conventional MOET programme and IVF

MOET

  • Starts with the donor cow receiving hormonal treatments, to encourage the production of multiple eggs.
  • The cow is inseminated after showing a standing heat and her embryos are flushed from the uterus a week later, before being transferred fresh into recipient females, or frozen in liquid nitrogen for future transfer.

IVF

  • Promotes high egg production, but it uses unfertilised eggs which are collected from the donor and transferred to a laboratory.
  • The donor cow is given an epidural anaesthetic, with an ultrasound vaginal probe carrying a guided needle used for egg removal. This process is known as ‘ovum pick-up’ (OPU).
  • The eggs are matured and fertilised 24 hours later, spending a further seven days in an incubator. The machine is designed to mimic the embryo’s natural environment, in terms of growing media, temperature and humidity.
  • The resulting embryos are transferred into recipient cows a week after the animals show a standing heat, or they can be stored in liquid nitrogen, using a ‘super-cooling’ technique called vitrification.

The overriding aim of MOET and IVF procedures is the same; to produce high numbers of viable embryos from animals of high genetic merit or with particular desirable traits, says Mr Black.

 

However, IVF offers the potential to harvest a higher number of progeny from a single animal, as the collection of eggs can be carried out within a shorter time frame and with greater flexibility.

Faster

IVF cycles can be managed on a fortnightly, or even weekly basis. By contrast, a typical MOET donor collection procedure operates on a 60-day cycle.

 

Embryos produced from either technique can be stored indefinitely in liquid nitrogen.

 

With IVF still a relatively new concept in the UK, Activf-ET is currently the only organisation offering the service.

 

It has three ovum pick-up (OPU) teams, situated in Cumbria, Cheshire and Yorkshire, and cows travel to the centres for egg collection.

 

At present, a charge for the procedure only applies if a successful pregnancy follows. The service, which is non-surgical and fairly straightforward, is in direct competition with ET. Mr Black predicts prices will come down as it is taken up more widely and the technique is refined further.

 

He says: “IVF can also be viewed as a genetic ‘insurance policy’. If it had been adopted before the foot-and-mouth outbreak, our national herd might look very different.

 

“Because we can collect eggs so frequently with IVF, there is the opportunity to use a different bull every week, if required. This means we can select from a wider pool of genetics and make faster genetic progress.”

 

The advances in cattle embryo production are likely to have a close affiliation to the rapidly developing use of genomics in the UK, says Mr Black.

 

“In Canada, techniques are being developed to assess the genomic make-up of an embryo, to provide information on the traits it is likely to exhibit,” he says.

 

“It is only a matter of time before this country follows suit. Using genomic predictions in conjunction with IVF means in future, a producer could order an embryo with known genomics to be transferred to his recipient cow on a particular day of his choosing.

 

“Access to embryo genomics, which includes the option to select the gender of the animal, could mean a producer will request a female embryo which has high health and fertility traits, good production traits, high immune status and even a level of TB resistance, for example.

 

“The use of IVF in cattle is not genetic manipulation; it is actually not unlike other breeding techniques - the main difference is that it is faster.

 

“IVF also fits in well with EBV. Although we can identify an animal’s genomic potential, we still cannot determine precisely how it will react to different environments.

 

“It may turn out to be suitable for housed systems, but will not perform so well when out at grass.”

 

While opportunities through advanced cattle breeding techniques may bring about change, there is still a place for the beef stock bull, stresses Mr Black.

 

“When AI came in during the 1940s, it was widely expected it would lead to the demise of the stock bull. But that did not happen and the same applies to IVF.

 

“People may still want to have their own bulls, for a variety of reasons. It could be that the top 25 per cent of cattle on a beef farm go into an IVF programme to produce replacements, with the remainder put to a bull.

 

Mr Black views IVF as a method of ‘amplifying’ the female line.

 

“One bull can inseminate thousands of cows, but the cow can only give birth once a year through natural service,” he says.

 

The bull is not the most valuable animal of the two - a cow which has produced an elite animal once has the potential to achieve the same degree of success in the future.

 

“We know we have to feed a growing population, with developing countries demanding more meat and milk proteins.

 

“Enhancing livestock performance is one way to achieve this goal. By selecting an embryo, rather than a calf, we are maximising the potential of our animals.

Maximising potential

“We might want to choose to have only female dairy calves and that will increase productivity. That said, some elite cattle breeders will still want to produce bull calves for breeding.”

 

It has been suggested the widespread use of IVF might lead to similarities between animals becoming exaggerated, but Mr Black refutes this idea.

 

Every farm is different and each has its own specific requirements, according to land type, location, soils and rainfall, as well as the farmer’s own personal preferences, he says.

 

“There are currently about 120 calves on the ground in the UK and Ireland which have been born through IVF and more are due soon.

 

“We have already worked with more than two dozen herds in both the beef and the dairy sector and numbers are expected to increase over the coming months,” says Mr Black.

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